H6pd (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase))

基因基本信息

H6pd 基因表型（MGI）

Mice homozygous for a knock-out allele show enlarged adrenal glands, reduced plasma corticosterone levels and altered 11 beta-hydroxysteroid dehydrogenase type 1 enzyme activity. Treatment with 11-dehydrocorticosterone fails to inhibit glucose-stimulated insulin secretion in pancreatic islets. Conditional KO in adipocytes results in decreased fat weight and increased glucose tolerance and insulin sensitivity.

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