Abraxas2 (BRISC complex subunit)

基因基本信息

Abraxas2 基因表型（MGI）

Mice homozygous for a knock-out allele exhibit reduced life span, decreased disease-free survival, increased susceptibility to tumor formation, and genomic instability in mouse embryonic fibroblasts. Mice homozygous for a different knock-out allele show defective activation of the NLRP3 inflammasome in bone marrow-derived macrophages, decreased interleukin-1 beta secretion and impaired immune cell recruitment in NLRP3-dependent peritonitis models induced by monosodium urate or aluminum, and increased survival in an LPS-induced sepsis model.

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