Prelp (proline arginine-rich end leucine-rich repeat)

基因基本信息

Prelp 基因表型（MGI）

Mice homozygous for a knock-out allele show disruption of the blood-brain barrier integrity causing leakage in the cerebellum and cortex, downregulation of basement membrane components, reduced pericyte coverage, decreased astrocyte end-feet, weakened adherens and tight junctions, and increased microglial activation.

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