Tirap (toll-interleukin 1 receptor (TIR) domain-containing adaptor protein)

基因基本信息

Tirap 基因表型（MGI）

Mutations in this gene lead to impaired cytokine secretion in response to TLR2 and TLR4 ligands. Homozygous null mice may also show low serum IgG3 levels, a reduced response to attenuated yellow fever vaccine, high susceptibility to bacterial infection, and altered response to myocardial infarction.

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