Bmpr2 (bone morphogenetic protein receptor type 2)

基因基本信息

Bmpr2 基因表型（MGI）

Homozygous null mutants arrest at the egg cylinder stage and die before embryonic day 9.5 with failure to form organized structure and lacking mesoderm. A heterozygous mutation that changes a cysteine residue in the extracellular ligand-binding domain of the protein leads to hyperproliferation of pulmonary artery smooth muscle cells (PASMCs).

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