Nr2f1 (nuclear receptor subfamily 2, group F, member 1)

基因基本信息

Nr2f1 基因表型（MGI）

Homozygotes for a null allele die perinatally with axon guidance defects in all forebrain commissures. Homozygotes for another null allele show neonatal death, impaired cranial ganglion IX formation and axon guidance, increased cochlear HC and support cell number, and altered cortex regionalization. Overexpression during embryonic development causes neonatal lethality, vestibular and cranial nerve anomalies (leading to circling), neuromuscular anomalies, and premature enteric neural crest cells (ENCCs) towards glial lineage (leading to aganglionic megacolon).

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