Ezh2 (enhancer of zeste 2 polycomb repressive complex 2 subunit)

基因基本信息

Ezh2 基因表型（MGI）

Homozygous null mutants die prior to completing gastrulation. A conditional mutant with loss of expression in immune cells survives, but has defects in early B cell development and Igh rearrangement. Conditional loss of maternal protein results in severe growth retardation of neonates. Conditional loss in oligodendrocytes affects their maturation and delays subsequent myelinization of axons in the central nervous system by oligodendrocytes. Homozygosity for a catalytically defective mutant is embryonic lethal, while heterozygosity affects bone formation and leads to increased body weight in females.

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