Krt17 (keratin 17)

基因基本信息

Krt17 基因表型（MGI）

Mice homozygous for a knock-out allele display age- and strain-dependent alopecia associated with frequent absence of vibrissae, increased hair fragility, abnormal hair cycling, altered hair follicle morphology, and apoptosis in matrix cells. Homozygosity for an allele expressing peptides with a non-functional NLS leads to enlarged skin keratinocyte nuclei.

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