Lmna (lamin A)

基因基本信息

Lmna 基因表型（MGI）

Homozygotes for targeted mutations exhibit retarded postnatal growth, muscular dystrophy, reduced fat stores, micrognathy, abnormal dentition, impaired gonadal development, malformed scapulae, hyperkeratosis, and die by 8 weeks of age. Heterozygosity for an atypical progeria syndrome (APS) associated mutation leads to changes in fat distribution, and diet-induced weight gain, insulin resistance, glucose intolerance and hypercholesteremia.

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