Mfn2 (mitofusin 2)

基因基本信息

Mfn2 基因表型（MGI）

Mice homozygous for disruptions in this gene die in mid-gestation. Structural and functional abnormalities of mitochondria are reported. Mice homozygous for a conditional allele in male germ cells exhibit small testes with abnormal sperm flagellum, aggregation of mitochondria, and disrupted male meiosis. Mice carrying the p.R707W lipodystrophy-associated mutation present with fat cell mitochondrial phenotypes.

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