Nfatc1 (nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1)

基因基本信息

Nfatc1 基因表型（MGI）

Homozygous mutation of this gene results in lethality throughout fetal growth and development due to cardiac failure. Mutants exhibit blood circulation, cardiac valve and ventricular septal abnormalities, edema, abdominal hemorrhage, and semilunar valveregurgitation. Homozygosity for sumoylation-blocking mutations leads to increased resistance to autoimmunity and alloreactivity.

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