Shc1 (src homology 2 domain-containing transforming protein C1)

基因基本信息

Shc1 基因表型（MGI）

Homozygotes with a targeted mutation of the exon encoding the CH2 region show an extended life span, reduced cellular sensitivity to oxidative stress and UV irradiation, and resistance to diet-induced atherogenesis. Homozygotes lacking all three isoformsdie around E11.5 with cardiovascular defects.

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