Fanci (Fanconi anemia, complementation group I)

基因基本信息

Fanci 基因表型（MGI）

Mice homozygous for a null allele exhibit male and female infertility associated with male germ cell apoptosis and increased accumulation of H3K9me3 on sex chromosomes. Mice homozygous for a gene trapped allele exhibit infertility, absent mature gametes, occasional fused digits, malocclusion, abnormal craniafacial morphology, increased cellular sensitivity to DNA damaging agents, microphthalmia, reduced body size, and inccompelte embryonic lethality.

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