Tbx6 (T-box 6)

基因基本信息

Tbx6 基因表型（MGI）

Homozygous null embryos die during organogenesis exhibiting defects in paraxial mesoderm differentiation, ectopic neural tube development, kinked neural tubes, impaired somite development, hematomas, enlarged tail buds, and laterality defects associated with nodal cilium anomalies. Adult mice heterozygous for a knock-out allele show increased piriform and secondary somatosensory cortex size in both sexes, a male-specific increase in cerebral cortex thickness and retrosplenial granular cortex size, and a female-specific increase in total brain area and area of the hippocampal fimbria. The p.P70T mutation leads to shorter tail.

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