Thbs4 (thrombospondin 4)

基因基本信息

Thbs4 基因表型（MGI）

Mice homozygous for a targeted allele exhibit increased sensitivity to cardiac pressure overload, including increased hypertrophy, decreased ejection fraction, decreased microvessel number, increased extracellular matrix deposition and increased fibrosis. Homozygous KO leads to impaired wound healing and delayed retinal vasculature development and affects macrophage differentiation. Homozygosity for the p.A389P mutation leads to enhanced wound healing and accelerated retinal vasculature development and affects macrophage differentiation.

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鼠来宝提供 Thbs4 相关基因敲除、条件敲除、人源化、点突变小鼠定制，以及配套动物实验、代养净化、检测研发服务。双繁育基地（鄂州葛店·广东佛山），标准化笼位 10 万+。