Thrb (thyroid hormone receptor beta)

基因基本信息

Thrb 基因表型（MGI）

Mice homozygous for a knock-out allele exhibit elevated T3, T4, and TSH serum levels, higher circulating and liver triglyceride levels, lower oxygen consumption, abnormal ear morphology, deafness, and abnormal thyroid morphology. Mice homozygous for an allele with point mutations exhibit disruption in thyroid hormone sensitivity. Homozygosity for a mutation that disturbs canonical ligand-receptor binding leads to increased body temperature, locomotor activity and oxygen consumption.

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