Tox (thymocyte selection-associated high mobility group box)

基因基本信息

Tox 基因表型（MGI）

Mice homozygous for a knock-out allele have a severe block in thymic positive selection leading to loss of CD4 T lineage cells, and display decreased NK cell numbers, severely reduced numbers of lymphoid tissue inducer cells, absence of all peripheral lymph nodes, and loss of Peyer's patches.

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