Sh3pxd2b (SH3 and PX domains 2B)

基因基本信息

Sh3pxd2b 基因表型（MGI）

Homozygous mutations of this gene result in decreased body size, pronounced craniofacial, skeletal, and cardiac defects, infertility, and eye anomalies including anterior segment dysgenesis, corneal opacities, and ocular hypertension. Mice homozygous for a spontaneous allele exhibit a calvarial phenotype characterized by disrupted suture patterning, reduced osteoregeneration, decreased cell proliferation, and impaired migration and podosome formation in neural crest-derived cells and tissues.

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