Zranb1 (zinc finger, RAN-binding domain containing 1)

基因基本信息

Zranb1 基因表型（MGI）

Homozygous knock-out allele leads to decreased CD4+ T cells and decreased susceptibility to experimental autoimmune encephalomyelitis. Homozygous enzymatic inactivation leads to reduced colon mucosa thickness and increased morbidity and mortality after DSS-induced colitis. Homozygosity for mutations associated with small brain size in human affects motor neuron and glial cell development, leading to motor deficits.

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