Unc93b1 (unc-93 homolog B1, TLR signaling regulator)

基因基本信息

Unc93b1 基因表型（MGI）

Mice with a transmembrane domain point mutation have no overt phenotype but fail to mount a normal cytokine response and exhibit increased susceptibility to mouse cytomegalovirus, Lysteria monocytogenes and Staphlococcus aureus. Antigen presentation by MHC class I and II is impaired. Mice carrying the p.V117L mutation allele have dosage-dependent SLE-like phenotypes.

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