Cox14 (cytochrome c oxidase assembly protein 14)

基因基本信息

Cox14 基因表型（MGI）

Mice homozygous for a missense point mutation show defective translation of the mitochondrial-encoded COX1 subunit and multi-systemic pathology affecting the heart, skeletal muscle, liver, and eye. Severe liver inflammation is linked to the highest reduction in complex IV activity, leading to increased mitochondrial ROS production and subsequent release of mitochondrial RNA into the cytoplasm of hepatocytes which triggers a type I interferon response and local inflammation in the liver.

获取 Cox14 基因编辑小鼠

鼠来宝提供 Cox14 相关基因敲除、条件敲除、人源化、点突变小鼠定制，以及配套动物实验、代养净化、检测研发服务。双繁育基地（鄂州葛店·广东佛山），标准化笼位 10 万+。