Optn (optineurin)

基因基本信息

Optn 基因表型（MGI）

Mice hypomorphic allele exhibit background sensitive embryonic lethality with surviving mice exhibiting normal immune cell development, T and B cell activation and TNF- or LPS-mediated activation of cells of the innate immune system. Homozygosity for the p.E50K mutation affects autophagy and apoptosis in the retina and leads to reduced visual function in aged mice.

获取 Optn 基因编辑小鼠

鼠来宝提供 Optn 相关基因敲除、条件敲除、人源化、点突变小鼠定制，以及配套动物实验、代养净化、检测研发服务。双繁育基地（鄂州葛店·广东佛山），标准化笼位 10 万+。