Opa1 (OPA1, mitochondrial dynamin like GTPase)

基因基本信息

Opa1 基因表型（MGI）

Mice homozygous for an ENU mutation exhibit embryonic lethality, embryonic growth retardation and morphological abnormalities. Mice heterozygous for an ENU mutation exhibit abnormal cellular morphology, altered optic nerve myelination, abnormal response to a new environment and decreased vision. Homozygosity for the disease-associated p.V291D/p.V309D variant leads to mitochondrial abnormalities in the retinal ganglion cells, which results in progressive RGC degeneration.

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鼠来宝提供 Opa1 相关基因敲除、条件敲除、人源化、点突变小鼠定制，以及配套动物实验、代养净化、检测研发服务。双繁育基地（鄂州葛店·广东佛山），标准化笼位 10 万+。