Mvp 基因位于小鼠第 7 号染色体(7 F3|7 69.26 cM),编码 protein-coding。鼠来宝提供该基因的基因敲除小鼠、条件敲除小鼠、点突变小鼠及配套动物实验服务。
| 基因符号 | Mvp |
|---|---|
| 英文全称 | major vault protein |
| 别名 | 2310009M24Rik | LRP | VAULT1 |
| 染色体 | 7 |
| 染色体定位 | 7 F3|7 69.26 cM |
| 基因类型 | protein-coding |
| MGI 编号 | MGI:1925638 |
Mice homozygous for a knock-out allele are viable, healthy and phenotypically normal with unimpaired dendritic cell maturation and function and normal resistance to various cytostatic agents. Adult mice homozygous for a gene trapped allele show male-specific brain neuroanatomical phenotypes including decreased total brain area, small brain nuclei associated with the limbic system, reduced corpus callosum, hippocampus, thalamus and cingulate gyrus size, decreased secondary somatosensory cortex size, abnormal neuron morphology, smaller mEPSC amplitude, and decreased dendritic spine density but no major behavioral deficits
鼠来宝提供 Mvp 相关基因敲除、条件敲除、人源化、点突变小鼠定制,以及配套动物实验、代养净化、检测研发服务。双繁育基地(鄂州葛店·广东佛山),标准化笼位 10 万+。
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